Clinical Challenge: Dark Lesion on Lower Lip MPR Are Freckles on Lips a Cause for Concern? Causes, Remedies Lip pigmentation Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in What Caused These Multiple Hyperpigmented Macules of the Mouth? Figure 7 from Pigmented lesions of the oral mucosa and perioral tissues: a flow chart for the diagnosis and some recommendations for the management. Semantic Scholar
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