Frontiers Glutathione: A Samsonian life sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation Glutathione Synthesis and Turnover in the Human Erythrocyte Journal of Biological Chemistry In RBCs, NADPH are produced exclusively via HMP shunt by the action of G6PD and are responsible to maintain membrane integrity preventing premature destruction. That is why G6PD deficient RBCs are L glutamine for sickle cell disease: more than reducing redox Annals of Hematology Springer Nature Link Heinz bodies are small clumps of damaged hemoglobin found inside red blood cells. They form due to oxidative stress and are often seen in conditions like G6PD deficiency. Their presence can indicate Response of Human Red Blood Cells to Acute and Chronic Oxidant Challenge as Observed Through the Glutathione and Glutathionyl Hemoglobin Redox Pairs In Vitro and In Vivo